发明名称 Phosphorus-containing compounds & uses thereof
摘要 This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA- in which: A is absent or is -O-, -S- or -NR<SUP>2</SUP>-; Q is absent or (if A is -O-, -S- or -NR<SUP>2</SUP>-) Q may be -V-, -OV-, -SV-, or -NR<SUP>2</SUP>V-, where V is an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, such that J is linked to the cyclohexyl ring directly, through A or through VA, OVA, SVA or NR<SUP>2</SUP>VA; K is O or S; each occurrence of Y is independently -O-, -S-, -NR<SUP>2</SUP>-, or a bond linking a R<SUP>5 </SUP>moiety to P; each occurrence of R<SUP>2 </SUP>and R<SUP>5 </SUP>is independently an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, or H; and each occurrence of R<SUP>6 </SUP>is independently -PK(YR<SUP>5</SUP>)(YR<SUP>5</SUP>), -SO<SUB>2</SUB>(YR<SUP>5</SUP>) or -(O)(YR<SUP>5</SUP>); so long as any R<SUP>2</SUP>, or R<SUP>5 </SUP>moiety linked directly to P is not H; wherein two R<SUP>2</SUP>, R<SUP>5 </SUP>and/or R<SUP>6 </SUP>moieties may be chemically linked to one another to form a ring; each occurrence of G is independently -O-, -S-, -NR<SUP>2</SUP>- or (M)<SUB>x</SUB>; each occurrence of M is independently a substituted or unsubstituted methylene moiety, and any M-M' moiety may be saturated or unsaturated; each occurrence of x is independently an integer from 1-6; and the other variables are as defined herein.
申请公布号 US2006264456(A1) 申请公布日期 2006.11.23
申请号 US20060494418 申请日期 2006.07.27
申请人 METCALF CHESTER A III;ROZAMUS LEONARD W;WANG YIHAN;BERSTEIN DAVID L 发明人 METCALF CHESTER A.III;ROZAMUS LEONARD W.;WANG YIHAN;BERSTEIN DAVID L.
分类号 A61K31/4745;A61L27/00;A61F2/84;A61K31/661;A61K31/662;A61K31/664;A61K45/00;A61K45/06;A61P1/04;A61P3/10;A61P9/00;A61P9/10;A61P11/00;A61P17/02;A61P17/04;A61P17/06;A61P19/02;A61P21/04;A61P25/00;A61P25/28;A61P27/02;A61P29/00;A61P31/10;A61P35/00;A61P35/02;A61P37/00;C07D491/14;C07D498/18;C07F9/09;C07F9/22;C07F9/32;C07F9/36;C07F9/40;C07F9/44;C07F9/46;C07F9/53;C07F9/6561 主分类号 A61K31/4745
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