TRI- OR TETRA-SUBSTITUTED-3-AMINOPYRROLIDINE DERIVATIVES

摘要

It is intended to provide quinolone type synthetic antibacterial agents having a potent antibacterial activity against a broad scope of gram-positive and gram-negative bacteria and a high safety and remedies for infections. A compound represented by the following general formula (I), its salt or hydrate thereof: I wherein R¹ and R² represent each hydrogen, etc.; R³ represents C_1-6 alkyl, etc.; R⁴ and R⁵ independently represent each hydrogen, C_1-6 alkyl, etc., provided that R⁴ and R⁵ are not hydrogen atoms at the same time, and the above substituents R⁴ and R⁵ may be united and form a spiro ring structure structure together with the pyrrolidine ring; R⁶ and R⁷ independently represent each hydrogen or C_1-6 alkyl; R⁸ represents a C_1-6 haloalkyl group, etc.; X¹ represents hydrogen or halogen; and A represents a nitrogen atom or a partial structure represented by the following general formula (II).