NOVEL COMPOUNDS

摘要

This invention relates to novel compounds useful in the treatment of diseases associated with TRPV4 channel receptor. More specifically, this invention relates to certain substituted amino -azepines, according to Formula (I). Specifically, the invention is directed to compounds according to Formula (I), wherein: R1 is optionally substituted C_3-7cycloalkyl, optionally substituted C_3-7cycloalkenyl, optionally substituted Het-C_3-7alkyl, optionally substituted Het-C_3-7-alkenyl, optionally substituted aryl, optionally substituted heterocycloalkyl, optionally substituted heteroaryl, or optionally substituted indenyl; R2 is H, optionally substituted C_1-6alkyl, C_3-6cycloalkyl-C_0-6alkyl, Ar-C_0-6alkyl, or Het-C_0-6alkyl; each R3 is independently H, optionally substituted C_1-8alkyl, optionally substituted C_2-8alkenyl, optionally substituted C_2-8alkynyl, Het-C_1-6 alkyl, optionally substituted C_3-6cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl, or optionally substituted C_1-C₆ alkoxy; R4 is H, or optionally substituted C_1-C₄ alkyl; R5 is H, optionally substituted C_1-8alkyl, optionally substituted C_2-8alkenyl, optionally substituted C_2-8alkynyl, optionally substituted C_3-6cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; R6 is H or C_1-6alkyl; and X is SO₂, CO, CH₂, or CONH, and pharmaceutically acceptable salts, hydrates, solvates and pro-drugs thereof.