摘要 |
A process for the preparation of a compound of formula (I): wherein Ar represents an optionally substituted aromatic carbocycle or heterocycle, and R<SUP>1 </SUP>and R<SUP>2 </SUP>independently represent hydrogen, C<SUB>1-10 </SUB>alkyl, C(O)C<SUB>1-10 </SUB>alkyl or optionally substituted aryl provided that R<SUP>1 </SUP>and R<SUP>2 </SUP>are not both hydrogen which process comprises reacting together a compound of formula (II): <?in-line-formulae description="In-line Formulae" end="lead"?>Ar-X (II)<?in-line-formulae description="In-line Formulae" end="tail"?> wherein Ar is as defined in relation to formula (I) and X represents a leaving group with a a compound of formula (III) wherein R<SUP>1 </SUP>and R<SUP>2 </SUP>are as defined in relation to formula (I) under aqueous conditions in the presence of a Pd (II) salt, a ligand and a Group I or Group II metal hydroxide base at a pH greater than 7. Compounds of formula (I) may be hydrolysed to the corresponding hydrazine.
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