发明名称 Pyrrolopyrimidines and related analogs as HSP90-inhibitors
摘要 The present invention provides compounds represented by Formula I. R<SUB>0 </SUB>is selected from hydrogen, halogen, lower alkyl, -SR<SUP>8</SUP>, -OR<SUP>8</SUP>, -CN, and -NHR<SUP>8</SUP>, R<SUB>1 </SUB>is halogen, or lower alkyl; R<SUB>2 </SUB>is -NHR<SUP>8</SUP>; R<SUB>3 </SUB>is selected from the group consisting of hydrogen, halogen, -SR<SUP>8</SUP>, -OR<SUP>8</SUP>, -CN, -C(O)R<SUP>9</SUP>, -C(O)OH, -NO<SUB>2</SUB>, -NR<SUP>8</SUP>R<SUP>10</SUP>, lower alkyl, lower alkenyl, lower alkynyl, lower perhaloalkyl, aryl, heteroaryl, alicyclic and heterocyclic, all optionally substituted, and R<SUB>5 </SUB>is aryl, heteroaryl, alicyclic, or heterocyclic:
申请公布号 US7138402(B2) 申请公布日期 2006.11.21
申请号 US20040945851 申请日期 2004.09.20
申请人 CONFORMA THERAPEUTICS CORPORATION 发明人 KASIBHATLA SRINIVAS R.;SHI JIANDONG;LE BRAZIDEC JEAN-YVES;BIAMONTE MARCO A.;HONG KEVIN D.;BOEHM MARCUS F.
分类号 C07D487/04;A61K31/519;A61K31/5377;A61K31/541;A61K31/675;A61P19/02;A61P31/16;A61P35/00;C07D;C07D473/12;C07D487/02;C07F9/02;C07F9/6515 主分类号 C07D487/04
代理机构 代理人
主权项
地址