发明名称 4-aminopyrimidine derivatives
摘要 This invention is 4-aminopyrimidine derivatives of the formula wherein R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3 </SUP>and R<SUP>4 </SUP>are as defined in the specification or a pharmaceutically acceptable salt thereof. The invention also is the preparation of compounds of formula I, pharmaceutical compositions containing therapeutically effective amounts of compounds of formula I or pharmaceutically acceptable salts thereof and to a method of treatment comprising administering therapeutically effective amounts of the compound of formula I for the prevention or treatment of mGluR5 receptor mediated disorders.
申请公布号 US7138404(B2) 申请公布日期 2006.11.21
申请号 US20020135150 申请日期 2002.04.29
申请人 HOFFMANN-LA ROCHE INC. 发明人 MUTEL VINCENT;PETERS JENS-UWE;WICHMANN JUERGEN
分类号 A61K31/513;C07D239/47;A61K31/505;A61K31/506;A61P1/00;A61P1/16;A61P3/10;A61P9/10;A61P13/02;A61P13/12;A61P19/02;A61P19/06;A61P21/00;A61P21/02;A61P25/00;A61P25/04;A61P25/06;A61P25/08;A61P25/14;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P25/34;A61P25/36;A61P27/02;A61P29/00;A61P29/02;A61P31/18;A61P35/00;A61P43/00;C07D239/46;C07D403/06;C07D405/06;C07D409/06;C07D413/06;C07D413/12;C07D413/14 主分类号 A61K31/513
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