发明名称 |
Method for producing a modified peptide |
摘要 |
The present invention is a method for producing a peptide or a protein in which a side chain contains a modified amino acid residue, which comprises chemically producing a peptide fragment containing an amino acid residue having a modified side chain using an weak acid-cleavable resin, producing a peptide fragment containing no amino acid residue having a modified side chain using a genetic recombination method or/and an enzymatic method, and condensing the resulting two kinds of peptide fragments and, according to the present invention, a peptide or a protein containing modification such as acylation, glycosylation and phosphorylation can be obtained effectively and at high quality.
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申请公布号 |
US7138489(B2) |
申请公布日期 |
2006.11.21 |
申请号 |
US20050500018 |
申请日期 |
2005.01.31 |
申请人 |
DAIICHI ASUBIO PHARMA CO., LTD.;KANGAWA KENJI |
发明人 |
MINAMITAKE YOSHIHARU;MATSUMOTO MASARU;MAKINO TOMOHIRO |
分类号 |
C07K1/00;A61K38/02;C07K1/04;C07K1/06;C07K1/08;C07K1/107;C07K9/00;C07K14/46;C07K14/465;C07K14/60 |
主分类号 |
C07K1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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