发明名称 |
AMIDE DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF |
摘要 |
Amide derivatives represented by general formula (I), or their salts and medicinal compositions containing these derivatives and pharmaceutically acceptable carriers, wherein each symbol has the following meaning: A: heteroarylene; X: a bond, O, S, -NR5-, -NR5 CO-, -NR5 CONH-, -NR5 SO2 - or -NR5 C(=NH)NH-; R1 : H, optionally substituted low er aryl, optionally substituted aryl, optionally substituted heteroaryl or optionally substituted cycloalkyl; R2a and R2b : being the sam e or different from each other and each representing H or lower alkyl; R3 : H or lower alkyl; R4a and R4b : being the same or different from each other and each representing H or OH, or R4a and R4b forming together =O or =N-O-lower alkyl; and R5 : H or lower alkyl. These compounds are useful as remedies for diabetes having an insulin secretion accelerating effect together with an insulin sensitivity increasin g effect.
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申请公布号 |
CA2272285(C) |
申请公布日期 |
2006.11.21 |
申请号 |
CA19982272285 |
申请日期 |
1998.01.22 |
申请人 |
YAMANOUCHI PHARMACEUTICAL CO., LTD. |
发明人 |
SUZUKI, TAKAYUKI;TAKAHASHI, TAKUMI;MATSUI, TETSUO;HAYAKAWA, MASAHIKO;ONDA, KENICHI;MARUYAMA, TATSUYA |
分类号 |
C07D233/64;A61K31/41;A61K31/415;A61K31/425;A61P3/10;A61P5/50;C07C217/16;C07C271/16;C07C271/20;C07D233/54;C07D233/61;C07D235/16;C07D249/08;C07D249/12;C07D257/04;C07D277/30;C07D277/38;C07D277/40;C07D277/42;C07D277/46;C07D285/12;C07D471/04 |
主分类号 |
C07D233/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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