| 摘要 |
This invention relates to a method and an agent for treating cardiovascular diseases, especially cardiac hypertrophy, wherein said method and agent consist in increasing testosterone concentration in pathological tissues to normal levels or inhibiting and/or eliminating metabolites from testosterone metabolism. The testosterone concentration in pathological tissues can be increased to normal levels by administering at least one substance from the following groups: testosterone; substances with effects similar to those of testosterone; testosterone mimetics; substances that enhance testosterone synthesis; substances that inhibit testosterone metabolism. Metabolites from testosterone metabolism can be inhibited and/or eliminated by administering at least one substance from the following groups: substances that bind to the androgen receptor, causing the receptor levels to be regulated and thus normalized; substances that bind to the androgen receptor, regulating the androgen receptor-mediated gene expression by inhibiting it, as is observed in cardiac hypertrophy. Areas of application are medicine and pharmaceuticals industry.
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