发明名称 |
Modulators of the P2Y10 receptor useful in altering T lymphocyte function |
摘要 |
The present invention relates to modulators of P2Y10. Various modulators are disclosed, including an antibody that binds specifically to P2Y10. The present invention also relates to methods of activating resting T lymphocytes and inhibiting the proliferation of activated T lymphocytes. Methods of upregulating trascription of P2Y10 mRNA in a resting T lymphocyte, methods of inducing expression of P2Y10 on the surface of a resting T lymphocyte and methods of activating a T lymphocyte are disclosed. Also disclosed are pharmaceuticals and methods of treating an immune disease.
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申请公布号 |
US2006257404(A1) |
申请公布日期 |
2006.11.16 |
申请号 |
US20060489829 |
申请日期 |
2006.07.20 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
BURKE JAMES R.;IOTZOVA VIOLETTA |
分类号 |
A61K39/395;A01N37/18;A61K;A61K38/16;A61K39/00;C07K16/00;C07K16/18;C07K16/28;C12N5/00;C12N5/06;C12N5/16;C12P21/08;G01N33/50;G01N33/53;G01N33/567 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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