AUXILIARY METHOD FOR DIAGNOSIS AND THERAPY OF CANCER WITH NUCLEOLIN

摘要

Based on the discovery that nucleolin is a specific receptor to endostatin, in the invention a kit is provided. The kit is used for detecting and screening the cancerous types and individuals that are adapted to be treated by using endostatin and other angiogenesis inhibitors. Specially, the detection kit c an include the antibody to nucleolin and DNA or RNA combined with coding nuclei c acids of nucleolin. In the invention, a screening method for angiogenesis inhibitors is provided, especially those similar inhibitors to endostatin. Furthermore, methods for specifically inhibiting growth of endothelial cells and generation of tumor blood vessels are provided by coupling cytotoxin suc h as tumor necrosis factor .alpha. with the antibody to nuleolin.