发明名称 |
N-THIOLATED 2-OXAZOLIDONE ANTIBIOTICS |
摘要 |
This invention describes the discovery and synthesis of N-thiolated 2-oxazolidinones as a new class of anti bacterial agents. These compounds can be synthesized from 2-oxazolidinones by Ndeprotection and N-sulfenylation. These new substances were found to exhibit potent anti-bacterial activity, including bacteriostatic properties against Staphylococcus spp., including methicillin resistant Staphylcoccus aureus (MRSA), and Bacillus spp., including Bacillus anthracis. |
申请公布号 |
CA2607660(A1) |
申请公布日期 |
2006.11.16 |
申请号 |
CA20062607660 |
申请日期 |
2006.05.08 |
申请人 |
UNIVERSITY OF SOUTH FLORIDA |
发明人 |
MISHRA, RAJESH KUMAR;TUROS, EDWARD |
分类号 |
C07D413/12;A61K31/421;C07D263/04 |
主分类号 |
C07D413/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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