NEW COMPOUNDS I

摘要

A compound of formula (I), or pharmaceutically acceptable salts thereof wherein X is selected from hydrogen, halo, -CN, -CON<SUB>2, </SUB>-CON(C<SUB>1</SUB>-<SUB>6</SUB>alkyl)H, -CON(C<SUB>1</SUB>-<SUB>6</SUB>alkyl)<SUB>2</SUB> and heterocyclic groups; R1 is selected from C<SUB>1</SUB>-<SUB>6</SUB>alkyl and C<SUB>3</SUB>-<SUB>6</SUB>cycloalkyl; whereby Z is -OH, M is selected from C(O)- , -CH(OR<SUP>a</SUP>) , N(R<SUP>a</SUP>) , and S(O)<SUB>r</SUB>-, wherein R<SUP>a</SUP> is hydrogen or C<SUB>1</SUB>-<SUB>6</SUB>alkyl and r is 0, 1 or 2, R2 is selected from C<SUB>1</SUB>-<SUB>6</SUB>alkyl, C<SUB>3</SUB>-<SUB>6</SUB>cycloalkyl, heterocycloalkyl, aryl, alkylaryl, and heteroaryl, R2 is substituted with halo, -NO<SUB>2</SUB>, -CN, -OH, -CF<SUB>3</SUB>, -OCF<SUB>3</SUB>, -NH<SUB>2</SUB>, and/or -CONH<SUB>2</SUB>, when Y is -C<SUB>1</SUB>-<SUB>6</SUB>alkyl; or Z is -C<SUB>1</SUB>-<SUB>6</SUB>alkoxy, M is bond, R2 is selected from C<SUB>1</SUB>-<SUB>6</SUB>alkyl, C<SUB>3</SUB>-<SUB>6</SUB>cycloalkyl, heterocycloalkyl, aryl, alkylaryl, and heteroaryl, when Y is -C<SUB>1</SUB>-<SUB>6</SUB>alkoxy.