THE PREPARATION PROCESS OF QUINAZOLINE DERIVATIVES AND APPLICATION FOR THE MANUFACTURE FOR THE TREATMENT OF TUMOR DISEASE

摘要

Provided are quinazoline derivatives of the compound (I), and its preparation process and application as a medicine of inhibit tumor growth. The group X, Y, Z, R<SUB>1</SUB>, R<SUB>2</SUB>, R<SUB>3</SUB>, R<SUB>4</SUB> of compound (I) are defined in the description. Compounds of the invention can selectively inhibit the phosphorylation of tyrosine kinase, and block the signal transduction path of tyrosine kinase, specially inhibit tyrosine kinase activity, thus to have the effect of inhibit the tumor vascularization, achieve the purpose of treating malignant tumor.