Antifungal formulation containing Streptomyces s.p.p., method for preparing the composition and relevant use

摘要

The present invention is a method for preparing a antifungal formulation containing a high concentration of spores comprising providing Streptomyces bacteria with sporulation competence; propagating the bacterial strain for obtaining spores under an appropriate condition, collecting the spores, preparing the spores to obtain a small scale of the spore biomass as a seed inoculum, and culturing the seed inoculum at 28 to 37° C., 80 to 250 rpm, 0.25 to 0.75 vvm and pH at 5.0 to 8.0 to obtain a large scale fermentation of the bacteria in a suitable broth medium. The present invention further comprises a antifungal formulation containing Streptomyces spp. comprising a high concentration of spores and a liquid medium for culturing spore biomass of Streptomyces spp.