AFFINITY ADSORBENTS FOR PLASMINOGEN

摘要

For the separation, removal, isolation, purification, characterisation, identification or quantification of plasminogen or a protein that is a plasminogen analogue, an affinity adsorbent is used that is a compound of formula (II) wherein one X is N and the other is N, C-Cl or C-CN; A is a support matrix, optionally linked to the triazine ring by a spacer; Z is O, S or N-R and R is H, C_1-6 alkyl, C_1-6 hydroxyalkyl, benzyl or ß-phenylethyl; B is an optionally substituted hydrocarbon linkage containing from 1 to 10 carbon atoms; D is H, OH or a primary amino, secondary amino, tertiary amino, quaternary ammonium, imidazole, guanidino or amidino group; or B-D is -CHCOOH-(CH₂)_3-4-NH₂; and q is 2 to 6.