THE PREPARATION PROCESS OF QUINAZOLINE DERIVATIVES AND APPLICATION FOR THE MANUFACTURE FOR THE TREATMENT OF TUMOR DISEASE

摘要

Provided are quinazoline derivatives of the compound (I), and its preparation process and application as a medicine of inhibit tumor growth. The group X, Y, Z, R<SUB>1</SUB>, R<SUB>2</SUB>, R<SUB>3</SUB>, R<SUB>4</SUB> of compound (I) are defined in the description. Compounds of the invention can specially inhibit tyrosine kinase activity, adjust VEGF secretion, thus to achieve the purpose of treating malignant tumor.