发明名称 |
DRUG COMBINATIONS COMPRISING (E)-7-[4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-[METHYL(METHYLSULFONYL)AMINO]PYRIMIDIN-5-YL](3R,5S)-3,5-DIHYDROXYHEPT-6-ENOIC ACID AND AN INHIBITOR, INDUCER OR SUBSTRATE OF P450 ISOENZYME 3A4 |
摘要 |
The invention concerns safe non-interacting drug combinations of a 3- hydroxy -3- methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, which is (E)-7- [4-(4-fluorophenyl) -6- isopropyl -2- [methyl (methylsulfonyl) amino] pyrimidin-5-yl] (3R,5S)-3,5- dihydroxyhept -6- enoic acid or a pharmaceutically acceptable salt thereof (the Agent) and a drug which is either an inducer, inhibitor or a substrate of cytochrome P450, in particular cytochrome P450 isoenzyme 3A4. Particular combinations are useful in treating hyperlipidaemia in humans who are receiving immunosuppressive chemotherapy. A preferred combination is the Agent and a fibrate drug, the use of such a combination in treating hyperlipidaemia in mammals, and medicaments containing such a combination for use in such treatments.
|
申请公布号 |
KR20060117381(A) |
申请公布日期 |
2006.11.16 |
申请号 |
KR20067021986 |
申请日期 |
2006.10.23 |
申请人 |
ASTRAZENECA AB;SHIONOGI & CO., LTD. |
发明人 |
RAZA ALI;PEARS JOHN STUART;HUTCHINSON HOWARD GERARD;SCHNECK DENNIS;BABA TAKAHIKO;TOUCHI AKIRA;YAMAGUCHI YOSHITAKA |
分类号 |
A61K9/48;A61K31/505;A61K;A61K31/216;A61K31/277;A61K31/352;A61K31/4178;A61K31/4422;A61K31/49;A61K31/554;A61K31/704;A61K45/00;A61K45/06;A61P;A61P3/06;A61P9/00;A61P37/06;A61P43/00 |
主分类号 |
A61K9/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|