发明名称 |
PYRIDONE DERIVATIVES FOR MODULATING STRESS-ACTIVATED PROTEINKINASE SYSTEM |
摘要 |
Disclosed are methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of at least one p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the at least one p38 MAPK by the compound. Also disclosed are derivatives of pirfenidone. These derivatives c an modulate a stress activated protein kinase (SAPK) system. |
申请公布号 |
CA2608116(A1) |
申请公布日期 |
2006.11.16 |
申请号 |
CA20062608116 |
申请日期 |
2006.05.09 |
申请人 |
INTERMUNE, INC. |
发明人 |
SEIWERT, SCOTT D.;BLATT, LAWRENCE M.;RADHAKRISHNAN, RAMACHANDRAN;BEIGELMAN, LEONID |
分类号 |
A61K31/44;A61K31/4412;A61K31/4704;A61P9/00;A61P11/00;A61P13/12;A61P29/00;A61P43/00 |
主分类号 |
A61K31/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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