发明名称 |
BIOLOGICAL LOW-MOLECULAR WEIGHT DERIVATIVES |
摘要 |
The crosslinking agents and condensing agents that have been employed in biological adhesives and in treating medical devices such as cardiac valves are non-natural compounds synthesized artificially. Thus, they are not metabolized in vivo and exhibit toxicity to living bodies. These compounds are thus used only in a restricted amount and for limited purposes in the clinical sites. The present invention provides a biological low-molecular-weight derivative obtained by modifying carboxyl groups of a biological low-molecular-weight compound with N-hydroxysuccinimide, N-hydroxysulfosuccinimide, or a derivative thereof and a crosslinked high-molecular-weight product obtained by crosslinking various high-molecular-weight compounds with this derivative. |
申请公布号 |
EP1548004(A4) |
申请公布日期 |
2006.11.15 |
申请号 |
EP20030795411 |
申请日期 |
2003.09.11 |
申请人 |
NATIONAL INSTITUTE FOR MATERIALS SCIENCE;FURUUCHI CHEMICAL CORPORATION |
发明人 |
TAGUCHI, TETSUSHI;KOBAYASHI, HISATOSHI;TANAKA, JUNZO;SAITO, HIROFUMI |
分类号 |
C07D285/00;A61L24/00;A61L27/00;C07C233/03;C07C235/06;C07C235/80;C07D207/02;C07D207/408;C07D207/46;C08H1/00 |
主分类号 |
C07D285/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|