An isolation bag for isolating a casualty from a contaminated environment. The bag is preferably fabricated from a transparent, biochemically resistive material and is specifically designed and configured to be utilized in combination with a self-contained transportable life support system. The isolation bag is further provided with a plurality of tubular passages which are designed to be filled with air provided by the transportable life support system to thus cause the isolation bag to expand and form a semi-rigid structure. A multiplicity of apertures are formed upon the tubular passages in such a manner that enables refreshed air to pass therethrough which washes over the patient in a head-to-toe direction such that rapid removal of toxic and infectious residues is facilitated.