发明名称 |
Method for down-regulation of amyloid |
摘要 |
A method for in vivo down-regulation of amyloid protein in an animal, including a human being, the method comprising effecting presentation to the animal's immune system of an immunogenically effective amount of at least one amyloidogenic polypeptide or subsequence thereof which has been formulated so that immunization of the animal with the amyloidgenic polypeptide or subsequence thereof induces production of antibodies against the amyloidogenic polypeptide, and/or at least one analogue of the amyloidogenic polypeptide wherein is introduced at least one modification in the amino acid sequence of the amyloidogenic polypeptide which has as a result the immunization of the animal with the analogue induces production of antibodies against the amyloidogenic polypeptide. |
申请公布号 |
US7135181(B2) |
申请公布日期 |
2006.11.14 |
申请号 |
US20010785215 |
申请日期 |
2001.02.20 |
申请人 |
PHARMEXA A/S |
发明人 |
JENSEN MARTIN ROLAND;RASMUSSEN PETER BIRK;NIELSEN KLAUS GREGORIUS |
分类号 |
A61K39/00;G01N33/53;A61K35/12;A61K35/66;A61K35/76;A61K38/00;A61K38/17;A61K38/18;A61K38/19;A61K38/20;A61K39/385;A61K39/39;A61K48/00;A61P25/28;C07K14/47;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12P21/02 |
主分类号 |
A61K39/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|