Fremgangsmåder til syntetisering af 2-chlor-9-(2-deoxy-2-fluor-beta-d-arabinofuranosyl)-9H-purin-6-amin
摘要
2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine is synthesized by reacting a 2-chloro-6-substituted purine with a protected and activated 2-deoxy-2-fluoro-D-arabinofiranose; and reacting with a base such as ammonia to provide 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine. When the purine reactant is substituted in the 6 position with a halogen, a reaction step with an alkoxide is carried out prior to the reaction with ammonia.
申请公布号
DK1261350(T3)
申请公布日期
2006.11.13
申请号
DK20010910961T
申请日期
2001.02.16
申请人
SOUTHERN RESEARCH INSTITUTE
发明人
MONTGOMERY, JOHN, A.;FOWLER, ANITA, T.;SECRIST, JOHN, A., III