| 摘要 |
FIELD: medicine, peptides. ^ SUBSTANCE: invention relates to biologically active compounds representing isolated derivatives of corticotropin-releasing factor. Invention presents non-native peptide of the formula: I-V-L-S-L-D-V-P-I-G-L-L-Q-I-L-L-E-Q-X19-K-X21-X22-X23-X24-X25-X26-Q-A-T-T-N-A-R-I-L-A-R-V (SEQ ID NO: 531) wherein (a) X19 is chosen from the group consisting of D and E; (b) X21 is chosen from the group consisting of A and Q; (c) X22 is chosen from the group consisting of R, E and K; (d) X23 is chosen from the group consisting of A, K and N; (e) X24 is chosen from the group consisting of A, E and L; (f) X25 is chosen from the group consisting of R and K; (g) X26 is chosen from the group consisting of E and Q. Isolated derivatives of corticotropin-releasing factor and nucleic acids encoding thereof are effective agents used in treatment of disorders modulated by corticotropin-releasing factor-2, such as muscular dystrophy. ^ EFFECT: valuable medicinal properties of agonists. |
