METHOD FOR PREPARING OPTICALLY ACTIVE TETRALINE

摘要

FIELD: organic chemistry, chemical technology. ^ SUBSTANCE: invention relates to a method for synthesis of optically active tetraline of the formula (I): . Synthesis is carried out from 5,8-dimethoxy-3,4-dihydronaphthalene by the following steps: (1) acylation in the presence of AlCl3 excess at temperature -35-25°C; (2) enantioselective dihydroxylation by Sharpless in the presence of the catalytic amount of osmium salt; (3) preparing 1-chloro-2-acetyl derivative; (3) dihydrochlorination and the following hydrolysis. Method provides the significant increasing the yield of the end substance. ^ EFFECT: improved method of synthesis. ^ 5 cl, 6 ex