| 发明名称 |
A CRE-LOX BASED METHOD FOR CONDITIONAL RNA INTERFERENCE |
| 摘要 |
The present invention relates to vectors, compositions and methods for conditional, Cre-lox regulated, RNA interference. Vectors for use in conditional expression of a coding sequence based on a strategy in which the mouse U6 promoter is modified to include a hybrid between a LoxP site and a TATA box, and their use in conditional expression in transgenic mice are disclosed. The vectors allow for spatial and temporal control of miRNA expression in vivo
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| 申请公布号 |
WO2005112620(A9) |
申请公布日期 |
2006.11.09 |
| 申请号 |
WO2005US12953 |
申请日期 |
2005.04.19 |
| 申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY;VENTURA, ANDREA;TYLER, E., JACKS |
发明人 |
VENTURA, ANDREA;TYLER, E., JACKS |
| 分类号 |
C12N15/00;A01K67/00;A01K67/027;C12N5/00;C12N5/02;C12N15/11;C12N15/113;C12N15/63;C12N15/85;C12N15/86 |
主分类号 |
C12N15/00 |
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