发明名称 |
Antibody against enzyme specifically cleaving von villebrand factor and assay system using the same |
摘要 |
It is intended to provide an antibody showing immunoreactivity selectively to ADAMTS-13 and applications of this antibody in epitope analysis or diagnosis of an ADAMTS-13 autoantibody-positive patient. Alternatively, it is intended to provide a process for producing and use of a modified ADAMTS-13 molecule partially deleted aiming at the application in pharmaceutical products. An antibody specific for ADAMTS-13 which can be obtained from a warm-blooded animal immunized and sensitized with a polypeptide containing a part or the whole of ADAMTS-13 amino acid sequence; a process for producing an antibody comprising a step of immunizing and sensitizing a warm-blooded animal with a polypeptide containing a part or the whole of ADAMTS-13 amino acid sequence; use of the above-described antibody including a method of detecting and purifying ADAMTS-13; and a modified ADAMTS-13 molecule partially deleted are provided.
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申请公布号 |
US2006251655(A1) |
申请公布日期 |
2006.11.09 |
申请号 |
US20050529009 |
申请日期 |
2005.03.24 |
申请人 |
SOEJIMA KENJI;MIMURA NORIKO;MAEDA HIROAKI;NOZAKI CHIKATERU;HAMAMOTO TAKAYOSHI;NAKAGAKI TOMOHIRO |
发明人 |
SOEJIMA KENJI;MIMURA NORIKO;MAEDA HIROAKI;NOZAKI CHIKATERU;HAMAMOTO TAKAYOSHI;NAKAGAKI TOMOHIRO |
分类号 |
A61K39/395;A61P7/02;C07H21/04;C07K16/40;C12N5/06;C12N9/64;C12N15/02;C12P21/06;C12P21/08;G01N33/53 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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