THERAPEUTIC AGENT FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE

摘要

Disclosed is a method for the prevention and/or treatment of a chronic obstructive pulmonary disease by administrating a 5-membered cyclic compound represented by the formula below or a pharmaceutically acceptable salt of the compound or a prodrug of the compound or salt: wherein X represents an oxygen or sulfur atom; R<SUP>1</SUP> represents a hydrogen atom, a substituted or unsubstituted alkyl or the like; R<SUP>2</SUP> represents a hydrogen atom, a substituted or unsubstituted alkyl or the like; Y<SUP>1</SUP> represents a single bond, a substituted or unsubstituted alkylene or the like; the wavy line means an (E) or (Z) coordination; R<SUP>3</SUP> represents a hydrogen atom, a substituted or unsubstituted aryl or the like; Y<SUP>2</SUP> represents a substituted or unsubstituted alkylene or an alkenylene; R<SUP>4</SUP> represents a hydrogen atom, a substituted or unsubstituted alkanoyl or the like; and R<SUP>5</SUP> represents a hydrogen atom or a substituted or unsubstituted alkyl.