发明名称 |
SUPERANTIBODY SYNTHESIS AND USE IN DETECTION, PREVENTION AND TREATMENT OF DISEASE |
摘要 |
Superantibodies having enhanced autophilic, catalytic, and/or membrane- penetrating properties are prepared by affinity-based conjugation of a photoactivatable organic molecule to a target immunoglobulin. The photoactivatable organic molecule bears a chromophoric aromatic hydrocarbon moiety, which has affinity for the immunoglobulin. Upon photolysis, the organic molecule is covalently linked to the immunoglobulin. A preferred organic molecule is a peptide and a preferred aromatic hydrocarbon moiety is a tryptophan residue. The photoactivatable organic molecule need not bear a purine, pyrimidine or azido group to effect binding to the immunoglobulin and/or photoactivation. The superantibodies can enhance the potency and expand the targeting range of target antibodies. Autophilic superantibodies can promote apoptosis of target cells and/or enhance therapeutic efficacies in the treatment of patients with diseases or disorders responsive to antibody therapy. Exemplary of such diseases are atherosclerosis and cardiovascular disease. Membrane-penetrating superantibodies can prevent apoptosis by binding to intracellular anti-caspase signal proteins. Compositions containing the superantibodies, as well as methods of making and using them, are disclosed. |
申请公布号 |
WO2006119291(A2) |
申请公布日期 |
2006.11.09 |
申请号 |
WO2006US16844 |
申请日期 |
2006.04.29 |
申请人 |
INNEXUS BIOTECHNOLOGY INTERNATIONAL LTD.;KOHLER, HEINZ;MULLER, SYBILLE;MORGAN, ALTON CHARLES, JR. |
发明人 |
KOHLER, HEINZ;MULLER, SYBILLE;MORGAN, ALTON CHARLES, JR. |
分类号 |
A61K39/395;A61K47/48;C07K16/28;C07K16/30;C07K16/32;C07K16/40;C07K16/46;G01N33/53;G01N33/574 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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