发明名称 |
THIOL-CLEAVABLE LINKAGE BETWEEN POLYMER AND LIGAND |
摘要 |
A conjugate comprised of a hydrophilic polymer covalently yet reversibly linked to a amine-, hydroxy- or carboxyl-containing ligand is described. The resulting conjugate is capable of releasing the parent amine, hydroxy, or carboxyl-containing compound via thiol-mediated cleavage. The system allows for delivery of various amino-, hydroxy-, or carboxy-containing drugs in the form of their thiolytically cleavable macromolecular conjugates. |
申请公布号 |
WO2005053749(A3) |
申请公布日期 |
2006.11.09 |
申请号 |
WO2004US41348 |
申请日期 |
2004.11.24 |
申请人 |
ALZA CORPORATION;ZALIPSKY, SAMUEL;KIWAN, RADWAN |
发明人 |
ZALIPSKY, SAMUEL;KIWAN, RADWAN |
分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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