| 摘要 |
The present application discloses compositions, methods and devices for treatment of degenerative cartilaginous structures of an arthritic joint, including articular cartilage and the meniscus. A composition can comprise chondrocytes expressing type II collagen and a biological macromolecule such as hyaluronic acid or a collagen. The chondrocytes can be obtained from hyaline cartilage of human cadavers up to about two weeks following death, and can be grown in vitro. A composition can be delivered to a recipient by intra-articular injection. Examples of joints into which a composition can be injected include a knee joint, a hip joint, a shoulder joint, an ankle joint, a wrist joint, a digit joint and an elbow joint.
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