摘要 |
The present inventions provide various embodiments of methods for one or more of treating vascular injury, neointima proliferation and/or local inflammation in a mammal by locally administering therapeutic compound comprising a mTOR targeting compound and a calcineurin inhibitor. In various aspects, the therapeutic compound comprises a bio-absorbable carrier component at least partially formed of a cellular uptake inhibitor and a cellular uptake enhancer, a mTOR targeting compound and a calcineurin inhibitor. In various aspects, the present invention provides for controlled delivery, which is at least partially characterized by total and relative amounts of a cellular uptake inhibitor and cellular uptake enhancer in a bio-absorbable carrier component. |
申请人 |
ATRIUM MEDICAL CORPORATION;HERWECK, STEVE, A.;MARTAKOS, PAUL;MOODIE, GEOFFREY;KARWOSKI, THEODORE;CARLTON, TREVOR |
发明人 |
HERWECK, STEVE, A.;MARTAKOS, PAUL;MOODIE, GEOFFREY;KARWOSKI, THEODORE;CARLTON, TREVOR |