发明名称 |
DOUBLE-STRANDED SYNTHETIC OLIGONUCLEOTIDES USEFUL FOR INDUCING APOPTOSIS OF OSTEOCLASTS FOR THE TREATMENT OF OSTEOPENIC PATHOLOGIES |
摘要 |
The invention relates to a synthetic double- stranded oligonucleotide capable of modifying the molecular phenotype of osteoclasts and increasing the expression of the oestrogen alpha receptor gene. Pharmaceutical compositions comprising the oligonucleotide according to the invention are also described, as well as therapeutic applications of that oligonucleotide, in particular for the treatment of osteopenic diseases such as for example osteoporosis . The oligonucleotide according to the invention is characterised in that it comprises the sequence 5'-ATTTATTTTCAATACTGACT-3' or a fragment or a mutant thereof . |
申请公布号 |
WO2006117600(A2) |
申请公布日期 |
2006.11.09 |
申请号 |
WO2006IB00741 |
申请日期 |
2006.03.30 |
申请人 |
UNIVERSITA' DEGLI STUDI DI FERRARA;ASSOCIAZIONE VENETA PER LA LOTTA ALLA TALASSEMIA;GAMBARI, ROBERTO;PENOLAZZI, LETIZIA;PIVA, ROBERTA |
发明人 |
GAMBARI, ROBERTO;PENOLAZZI, LETIZIA;PIVA, ROBERTA |
分类号 |
A61K31/713;A61P19/08;C12N15/113 |
主分类号 |
A61K31/713 |
代理机构 |
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地址 |
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