METHOD OF ASYMMETRICALLY REDUCING 4-[5-(IMIDAZOL-1-YL)-2-METHYLBENZOYL]-3,5-DIMETHYLBENZOIC ACID OR ESTER THEREOF

摘要

The invention relates to a method of producing an optically active 4-[hydroxy[5-(imidazol-1-yl)-2-methylphenyl]methyl]-3,5-dimethylbenzoic acid or an ester thereof, which includes reacting 4-[5-(imidazol-1-yl)-2-methylbenzoyl]-3,5-dimethylbenzoic acid or an ester thereof with a silane agent in the presence of a particular zinc compound and an optically active diamine compound.