发明名称 |
IL-15 BINDING SITE FOR IL 15-RALPHA AND SPECIFIC IL-15 MUTANTS HAVING AGONIST/ANTAGONIST ACTIVITY |
摘要 |
The present invention relates to the identification of an epitope in human Interleukin-15 (IL-15) that is responsible for binding to the interleukin-15 receptor α-chain. Two IL-15 regions are involved in the formation of this epitope: the first region (44LLELQVISL52, peptide 1) corresponds to a sequence located in the B helix and the second (64ENLIL68, peptide 2 or 64ENLIIL69, peptide 2a) to a sequence located in helix C. Muteins displaying agonist or antagonist properties are described, and may be useful as therapeutic agents. |
申请公布号 |
EP1718670(A1) |
申请公布日期 |
2006.11.08 |
申请号 |
EP20050707720 |
申请日期 |
2005.02.10 |
申请人 |
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) |
发明人 |
BERNARD, JEROME;PLET, ARIANE;JACQUES, YANNICK;HARB, CATHERINE;QUEMENER, AGNES;MORTIER, ERWAN |
分类号 |
C07K14/54;A61K38/00;C07K7/06;C07K7/08 |
主分类号 |
C07K14/54 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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