发明名称 |
METHOD OF IN VITRO DIFFERENTIATION OF NEURAL STEM CELLS, MOTOR NEURONS AND DOPAMINE NEURONS FROM PRIMATE EMBRYONIC STEM CELLS |
摘要 |
A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1- /Pax6+ in the presence of FGF2, FGF4, FGF8, FGF9, or RA wherein the cells are characterized by an neural tube-like rosette morphology and are Pax6+/Sox1+.
|
申请公布号 |
KR20060115351(A) |
申请公布日期 |
2006.11.08 |
申请号 |
KR20067004226 |
申请日期 |
2006.02.28 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
ZHANG SU CHUN;THOMSON JAMES A.;DUNCAN IAN DAVID;LI XUE JUN |
分类号 |
C12N5/02;C12N;C12N5/00;C12N5/0793 |
主分类号 |
C12N5/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|