MOLECULAR SPACER, PRODUCTION METHOD THEREOF AND USES OF SAME ON AN ANALYSIS CHIP WITH MOLECULES OR BIOMOLECULES

摘要

A molecular spacer arm for attaching (bio)molecules to analytical chips, is new. Molecular spacer arm of formula (I) for attaching (bio)molecules to analytical chips. [mo]-X 4>-[X 3>(R 3>)] p-CH 2-N(Gp)-[X 2>(R 2>)] m-Z 2>=Z 1>-CH 2-[X 1>(R 1>)] n-X 0>-[Sup] (I) X 0> and X 4> = C, O, N, S, Se, P, As or Si; X 1>, X 2> and X 3> = as X 0> or also 2-20C (hetero)aryl; Z 1> and Z 2> = C-R, Si-R, C, N, P or As; R = 1-40C alkyl; R 1>, R 2> and R 3> = hydrogen, or 2-20C alkyl or (hetero)aryl; Gp = protecting group for secondary amino or a molecule that participates in the functioning of the spacer arm; n, m and p = integer 1 or more, especially 1-40; Sup = hydrogen or a solid silanized support on which the spacer can be attached covalently; mo = hydrogen or molecular unit that is to be fixed covalently to the support, through the spacer An independent claim is also included for a method of covalent attachment of mo to a support through a spacer arm.