发明名称 USE OF 2,5-DIHYDROXYBENZENESULPHONIC ACID IN THE PRODUCTION OF MEDICAMENTS FOR THE TREATMENT OF ANGIOGENESISDEPENDENT DISEASES SUCH AS CANCER AND PSORIASIS
摘要 <p>The invention relates to the use of 2,5-dihydroxybenzenesulfonic acid in the production of medicaments for the treatment of angiodependent diseases. More specifically, the invention relates to the use of the aforesaid compound and, in particular, the calcium and potassium salts thereof, for the treatment of two angiodependent diseases, which present a reduction in the apoptosis, namely cancer and psoriasis. The invention also discloses the antiproliferative, antimigratory, antiangiogenic and proapoptotic capacity of said family of compounds in non-quiescent cells. In addition, the invention details the potentiating effect of said compounds on known cytostatic medicines in the treatment of tumours and, specifically, on gliomas. The invention further relates to the therapeutic efficacy of said compounds, based on the combined antiproliferative, antiangiogenic and proapaptotic capacities threof, in the treatment of chronic psoriatic plaques.</p>
申请公布号 EP1719509(A1) 申请公布日期 2006.11.08
申请号 EP20050708114 申请日期 2005.02.16
申请人 ACTION MEDICINES, S.L. 发明人 CUEVAS SANCHEZ, PEDRO;ROMERO GARRIDO, ANTONIO;VALVERDE LOPEZ, SERAFIN;LOZANO PUERTO, ROSA MARIA;GIMENEZ GALLEGO, GUILLERMO
分类号 A61K31/185;A61K31/255;A61P17/06;A61P35/00 主分类号 A61K31/185
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