DIACYL-SUBSTITUTED GUANIDINES, A PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINE OR DIAGNOSTIC AID, AND MEDICINE CONTAINING THEM

摘要

Diacyl-substituted guanidines of the formula I (see formula I) are described where X(1) and x(2) are (see formula II) T1 is zero, 1, 2, 3 or 4, R(A) and R(B) are hydrogen, Hal, CN, OR(106), (O)(cyclo)- (fluoro)alkyl, NR(107)R(108), phenyl or benzyl, or X(1) and x(2) are (see formula III) T2a and T2b are, independently of each other, zero, 1 or 2, where the double bond can be in the E or Z con- figuration; or X(1) and X(2) arm (see formula IV) as are the pharmaceutically tolerated salts thereof. They are outstandingly suitable for use as antiarrhythmic pharmaceuticals possessing a cardioprotective component for the prophylaxis and treatment of infarction and for the treatment of angina pectoris, in connection with which they also inhibit or strongly reduce, in a preventive manner, the pathophysiological processes associated with the genesis of ischemically induced damage, in particular associated with the elicitation of ischemically induced cardiac arrhythmias. On account of their protective effects against pathological hypoxic and ischemic situations, the compounds of the formula I according to the invention can, as a consequence of inhibiting the cellular Na+/H+ exchange mechanism, be used as pharmaceuticals for treating all acute or chronic damage elicited by ischemia, or diseases induced primarily or secondarily thereby.