| 摘要 |
A new process is described for preparing imidazopyridines of the general formula: (see formula I) wherein R1 is an alkyl, cycloalkyl, aryl or aralkyl group or is a heterocyclic radical, R2 and R4 are identical or different and each represents hydrogen, a hydroxy, a cyano, alkyl, cycloalkyl, aryl or aralkyl group or an alkanoyl or an alkoxycarbonyl group and R3 is hydrogen, an alkyl, aryl or aralkyl group or a halogen atom. In the key step of the process, an imidate of the formula: (see formula II) is cyclized with aminoacetonitrile and a 1,3-dicarbonyl compound of the general formula: (see formula III) The imidazopyridines (I) are valuable intermediates for the preparation of angiotensin II antagonists.
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