| 摘要 |
<p>A process for the preparation of spiro[cis-4-(beta- hydroxyethyloxy)cyclohexane-[3H]-2'[1'H]-one derivatives of the formula (I) wherein R1 and R2 stand independently from each other for hydrogen, C1-4alkyl, C1-4alkoxy, C1-4alkylthio, C1-4polyfluroalkyl, C1-4polyfluroalkoxy, C3-7cycloalkyloxy, C3-7cycloakylthio, phenoxy, benzyloxy or nitro group by reduction of a dispiro[(1,3-dioxolane)-2,4'-cyclohexane-1',3''-[3H]indol]- 2''[1''H]-one derivative of general formula (II), wherein R1 and R2 are as defined above, which comprises carrying out the reduction (a) with sodium cyanoborohydride in the presence of a Lewis acid, or (b) with sodium borohydride in the presence of a strong acid.</p> |
