MEDICINAL PREPARATION FOR PERCUTANEOUS ABSORPTION

摘要

A medicinal preparation for percutaneous absorption characterized by comprising a hygroscopic packaging material and, packed therein, a pressure-sensitive adhesive patch which comprises a substrate and formed thereon a pressure-sensitive adhesive layer and in which the pressure-sensitive adhesive layer contains ketotifen fumarate and tris(hydroxymethyl)aminomethane. The medicinal preparation for percutaneous absorption contains tris(hydroxymethyl)aminomethane, which was especially selected among many basic substances, and this substance has been packed in a hygroscopic packaging material. Due to this, percutaneous drug absorbability and drug content stability can be simultaneously improved and yellowing can be inhibited. These effects can be further improved by adding propyl gallate, by using a pressure-sensitive adhesive layer comprising an SIS type pressure-sensitive adhesive base and a rosin ester tackifier resin, and/or by removing oxygen from the atmosphere in the packing material.