Heterocyclic compounds having inhibitory activity against HIV integrase

摘要

A heterocyclic compound of the formula (I): wherein B¹ is -C(R²)- or -N-; R¹' is H, etc.; one of R¹ and R² is -Z¹-Z²-Z³-R⁵ wherein Z¹ and Z³ are independently single bond, optionally substituted alkylene, etc.; Z² is single bond, optionally substituted alkylene, etc.; R¹ is optionally substituted aryl, optionally substituted heteroaryl, etc., and the other of R¹ and R² is H; -A¹- is -C(-Y)-C(-R^A)-C(-R³)-C(-R⁴)-, etc. wherein Y is OH, etc.; R^A is -COR⁷ wherein R⁷ is OH, etc.; one of R³ and R⁴ is carboxy, etc., and the other of R¹ and R² is H, etc, a prodrug thereof, a pharmaceutically acceptable salt thereof, and a solvate thereof, having an antiviral activity, more particularly, an inhibitory activity against HIV integrase, and a pharmaceutical composition containing the same, especially an anti-HIV drug.