SYNTHESIS OF ACYLOXYALKYL CARBAMATE PRODRUGS AND INTERMEDIATES THEREOF
摘要
Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates.
申请公布号
EP1716115(A2)
申请公布日期
2006.11.02
申请号
EP20040815821
申请日期
2004.12.30
申请人
XENOPORT, INC.
发明人
GALLOP, MARK A.;DAI, XUEDONG;SCHEUERMAN, RANDALL A.;RAILLARD, STEPHEN P.;MANTHATI, SURESH K.;YAO, FENMEI;PHAN, THU;LUDWIKOW, MARIA;PENG, GE;BHAT, SEEMA