IRTA-1 ANTIBODIES AND THEIR USES

摘要

The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to IRTA-I with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting IRTA-I, as well as methods for treating various B cell malignancies, including Multiple Myeloma and diffuse large B cell lymphomas.