| 发明名称 |
PREVENTIVES FOR MIGRAINE |
| 摘要 |
<p>The present invention relates to prophylactic antimigraine agents comprising as an active ingredient a dual antagonist for the 5-HT 2B and 5-HT 7 receptors, the antagonist having a binding affinity selective for the 5-HT 2B and 5-HT 7 receptors. Since these prophylactic antimigraine agents show an excellent pharmacological effect in comparison with the cases in which a 5-HT 2B receptor antagonist having a selective binding affinity to the 5-HT 2B receptor or a 5-HT 7 receptor antagonist having a selective binding affinity to the 5-HT 7 receptor is used alone, they are useful as drugs which are excellent in prophylaxis of migraine and in which the side effects found in the existing prophylactic antimigraine agents are reduced.</p> |
| 申请公布号 |
EP1716867(A1) |
申请公布日期 |
2006.11.02 |
| 申请号 |
EP20050710598 |
申请日期 |
2005.02.17 |
| 申请人 |
ASTELLAS PHARMA INC. |
发明人 |
AKUZAWA, SHINOBU;WATANABE, TOSHIHIRO |
| 分类号 |
A61K45/00;A61K31/166;A61K31/454;A61K31/505;A61K45/06;A61P25/06;A61P43/00;C07D239/42;C07D339/06;C07D401/06 |
主分类号 |
A61K45/00 |
| 代理机构 |
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