GEM DIFLUORINATED C-GLYCOPEPTIDES, THEIR PREPARATION AND THEIR USE FOR THE PRESERVATION OF BIOLOGICAL MATERIALS AND/OR IN CRYOSURGERY

摘要

The invention concerns a gem-difluorinated C-glycopeptide compound of formula (I) in which N is an integer between 1 and 5, R⁴= H, AA₁, AA₁-AA₂ and R⁵= OH, AA₁, AA₁.AA₂, with AA₁, and AA₂ are independents and representing amino acids with a non-functionalised side chain and R¹, R², R³ are independent groups and one of them is egal to formula (II), in which n is an integer between 3 and 4, Y, Y' are independent groups in which Y, Y'= H, OR, N₃, NR'R", SR'", where R = H, benzyl, trimethylsilyl, tert-butyldimethylsilyl, tert-butyldiphenylsilyl, acetate group, R', R" = H, alkyl, allyl, benzyl, tosylate group, C(=0)-alkyl, C(=O)-Bn, R"' = H, alkyl, acetate group, R⁶ is notably a group H, CH₃, CH₂OH, CH₂-Glycoside group, CH₂-OGP in which GP is a protector group such as an alkyl, benzyl, trimethylsilyl, tert-butyldimethylsilyl, tert­butyldiphenylsilyl, acetate group, and R⁷ = OH, OGP', NH₂, N₃, NHGP', NGP'GP" in which GP' and GP" is or not a protector group such as an alkyl, benzyl, trimethylsilyl, tert­butyldimethylsilyl, tert-butyldiphenylsilyl, acetate group, and R^B is a hydrogen atom H or a free or protected alcohol function. It applies notably to preservation of biological materials and to cryosurgery.