Conjugate compositions are disclosed that include a specific-binding moiety covalently coupled to a nanoparticle through a heterobifunctional polyalkyleneglycol linker. In one embodiment, a conjugates is provided that includes a specific-binding moiety and. a fluorescent nanoparticle coupled by a heterobifunctional PEG linker. Fluorescent conjugates according to the disclosure can provide exceptionally intense and stable signals for immunohistochemical and in situ hybridization assays on tissue sections and cytology samples, and enable multiplexing of such assays.
申请公布号
WO2006116742(A2)
申请公布日期
2006.11.02
申请号
WO2006US16444
申请日期
2006.04.28
申请人
VENTANA MEDICAL SYSTEMS, INC.;BAUER, CHRISTINA;BIENIARZ, CHRISTOPHER;HARTMAN, ANTHONY L.
发明人
BAUER, CHRISTINA;BIENIARZ, CHRISTOPHER;HARTMAN, ANTHONY L.