发明名称 |
CHAPERONIN 10 MODULATION OF TOLL-LIKE RECEPTOR-INDUCIBLE CYTOKINE AND CHEMOKINE SECRETION |
摘要 |
Methods of use of Chaperonin 10 (Cpn10) are provided for regulating Toll-like receptor signaling and/or Toll-like receptor inducible immunomodulator secretion. Cpn10 negatively regulates Toll-like receptor agonist-induced pro-inflammatory cytokine and chemokine secretion, examples being IL-6 and RANTES, respectively. Cpn10 positively regulates Toll-like receptor agonist-induced anti-inflammatory cytokine and chemokine secretion, an example being IL-10. These immunoregulatory activities of Cpn10 may be useful in the treatment of diseases, disorders and conditions resulting from excessive pro-inflammatory cytokine and chemokine secretion. This invention also relates to producing, designing and/or screening Cpn10 agonists and antagonists according to their ability to regulate Toll-like receptor signaling and/or Toll-like receptor inducible immunomodulator secretion. |
申请公布号 |
EP1715884(A1) |
申请公布日期 |
2006.11.02 |
申请号 |
EP20050700073 |
申请日期 |
2005.01.14 |
申请人 |
CBIO LIMITED |
发明人 |
JOHNSON, BARBARA JANE;SUHRBIER, ANDREAS;NAYLOR, DEAN JASON;DOBBIN, CAROLINE AMANDA;HOWARD, CHRISTOPHER BRUCE |
分类号 |
A61K38/16;A61K38/17;A61K47/48 |
主分类号 |
A61K38/16 |
代理机构 |
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