发明名称 |
UBIQUILIN REGULATION OF PRESENILIN ENDOPROTEOLYSIS, AND SUPPRESSION OF POLYGLUTAMINE-INDUCED TOXICITY IN CELLS |
摘要 |
<p>Use of ubiquilin is described, including utilization for reducing fragmentation of presenilin 1 and 2 and to modulate ?-secretase components, Pen-2 and Nicastrin, as well as utilization for inducing increased levels of ubiquilin to reduce aggregation of polyglutamine expansion proteins known to cause cell toxicity and cell death in subjects suffering from neurodegenerative diseases, such as Huntington's and Alzheimer's diseases.</p> |
申请公布号 |
WO2006115951(A2) |
申请公布日期 |
2006.11.02 |
申请号 |
WO2006US14795 |
申请日期 |
2006.04.19 |
申请人 |
UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTTUTE OFF. OF RESEARCH ADMIN/TECH. DEV.;MONTEIRO, MERVYN, J.;WANG, HONGMIN |
发明人 |
MONTEIRO, MERVYN, J.;WANG, HONGMIN |
分类号 |
A61K48/00 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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地址 |
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